CD8⁺ T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls.

ABSTRACT:

Background

Genetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS.

Objectives

Analysis of the gene expression profiles of circulating CD8⁺ T cells of MS patients compared to healthy controls.

Methods

RNA from purified CD8⁺ T cells was sequenced and analyzed for differential gene expression. Pathway analyses of genes at several p-value cutoffs were performed to identify putative pathways involved.

Results

We identified 36 genes with significant differential gene expression in MS patients. Four genes reached at least 2-fold differences in expression. The majority of differentially expressed genes was high

SUBMITTER: Brorson IS 

PROVIDER: S-EPMC7731718 | biostudies-literature | 2020 Oct-Dec

REPOSITORIES: biostudies-literature