Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis.

ABSTRACT: Cilia are microtubule-based organelles that function in a multitude of physiological contexts to perform chemosensing, mechanosensing, and fluid propulsion. The process of ciliogenesis is highly regulated, and disruptions result in disease states termed ciliopathies. Here, we report that peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a) is essential for ciliogenesis in nodal, mono-, and multiciliated cells (MCCs) and for discernment of renal tubule ciliated cell fate during embryogenesis. ppargc1a performs these functions by affecting prostaglandin signaling, whereby cilia formation and renal MCC fate are restored with prostaglandin E₂ (PGE₂) treatment in ppargc1a-deficient animals. Genetic disruption of ppargc1a specifically reduces exp

SUBMITTER: Chambers JM 

PROVIDER: S-EPMC7731726 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature