Economic evaluation of supplementing the diet with Souvenaid in patients with prodromal Alzheimer's disease.

ABSTRACT:

Background

The LipiDiDiet trial showed that Souvenaid, a medical food, might delay progression to dementia in prodromal Alzheimer's disease (AD). The objective of this study was to assess the cost-utility of Souvenaid compared to placebo in patients with prodromal AD under the conditions applied in that trial.

Methods

A discrete event simulation model was developed based on the LipiDiDiet trial and a literature review to assess the cost-utility of Souvenaid from a societal perspective considering direct and indirect costs. For both intervention and control groups, patient trajectories in terms of functional decline on the Clinical Dementia Rating Sum of Boxes (CDR-SB) scale in LipiDiDiet were reproduced statistically with mixed models by assigning time until events to simula

SUBMITTER: Mar J 

PROVIDER: S-EPMC7731786 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature