TL1A (TNFSF15) genotype affects the long-term therapeutic outcomes of anti-TNFα antibodies for Crohn's disease patients.

ABSTRACT:

Background and aim

TL1A (TNFSF15) is a major Crohn's disease (CD) susceptibility gene, especially in the East Asian population, and is also known to be associated with some clinical phenotypes, such as stricturing and penetrating behavior. This study aims to investigate the association between TL1A genotype and the long-term therapeutic outcomes of infliximab and adalimumab in Japanese CD patients.

Methods

We investigated 119 biologic-naïve CD patients treated with infliximab or adalimumab. TL1A -358C/T (rs6478109) was genotyped as a tag single nucleotide polymorphism (SNP) for CD risk or nonrisk haplotype of TL1A (the -358C allele is a risk allele for CD development). We compared the long-term therapeutic outcomes of anti-tumor necrosis fa

SUBMITTER: Endo K 

PROVIDER: S-EPMC7731806 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature