CEG 2.0: an updated database of clusters of essential genes including eukaryotic organisms.

ABSTRACT: Essential genes are key elements for organisms to maintain their living. Building databases that store essential genes in the form of homologous clusters, rather than storing them as a singleton, can provide more enlightening information such as the general essentiality of homologous genes in multiple organisms. In 2013, the first database to store prokaryotic essential genes in clusters, CEG (Clusters of Essential Genes), was constructed. Afterward, the amount of available data for essential genes increased by a factor >3 since the last revision. Herein, we updated CEG to version 2, including more prokaryotic essential genes (from 16 gene datasets to 29 gene datasets) and newly added eukaryotic essential genes (nine species), specifically the human essential genes of 12 cancer cell lines.

SUBMITTER: Liu S 

PROVIDER: S-EPMC7731928 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature