Differential genes expression analysis of invasive aspergillosis: a bioinformatics study based on mRNA/microRNA.

ABSTRACT: Invasive aspergillosis is a severe opportunistic infection with high mortality in immunocompromised patients. Recently, the roles of microRNAs have been taken into consideration in the immune system and inflammatory responses. Using bioinformatics approaches, we aimed to study the microRNAs related to invasive aspergillosis to understand the molecular pathways involved in the disease pathogenesis. Data were extracted from the gene expression omnibus (GEO) database. We proposed 3 differentially expressed genes; S100B, TDRD9 and TMTC1 related to pathogenesis of invasive aspergillosis. Using miRWalk 2.0 predictive tool, microRNAs that targeted the selected genes were identified. The roles of microRNAs were investigated by microRNA target prediction and molec

SUBMITTER: Hosseinipour M 

PROVIDER: S-EPMC7731968 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature