Laboratory-confirmed influenza infection and acute myocardial infarction among United States senior Veterans.

ABSTRACT:

Background

Previous studies established an association between laboratory-confirmed influenza infection (LCI) and hospitalization for acute myocardial infarction (AMI) but not causality. We aimed to explore the underlying mechanisms by adding biological mediators to an established study design used by earlier studies.

Methods

With data on biomarkers, we used a self-controlled case-series design to evaluate the effect of LCI on hospitalization for AMI among Veterans Health Administration (VHA) patients. We included senior Veterans (age 65 years and older) with LCI between 2010 through 2015. Patient-level data from VHA electronic medical records were used to capture laboratory results, hospitalizations, and baseline patient characteristics. We defined the "risk interval" as th

SUBMITTER: Young-Xu Y 

PROVIDER: S-EPMC7732109 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature