Recent insights into Fc-mediated effector responses to HIV-1.

ABSTRACT:

Purpose of review

Recent work defining Fc-mediated effector functions for both viral control and protection against infection is summarized and considered along with new strategies to drive robust Fc-mediated responses.

Recent findings

In new human and nonhuman primate (NHP) vaccine trials as well as studies of natural infection, Fc-mediated effector responses have sometimes been observed to correlate with decreased risk of infection or with better clinical outcomes, suggesting a potential role for these responses in HIV-1 prevention and therapy. Recent highlights include use of antibody-dependent cellular cytotoxicity-sensitizing CD4-induced mimetic compounds, novel V1V2 immunogens, passive transfer studies, and vaccine regimens that successfully elicited Fc-mediated respon

SUBMITTER: Carpenter MC 

PROVIDER: S-EPMC7732205 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature