Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies.

ABSTRACT:

Objective

Lewy body (LB) synucleinopathies such as Parkinson's disease (PD) entail profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic innervation at other extracranial sites has been unclear. Although in vivo neuroimaging studies have indicated a cardioselective noradrenergic lesion, no previous study has surveyed peripheral organs for norepinephrine contents in LB diseases. We reviewed ¹⁸ F-dopamine (¹⁸ F-DA) positron emission tomographic images and postmortem neurochemical data across several body organs of controls and patients with the LB synucleinopathies PD and pure autonomic failure (PAF) and the non-LB synucleinopathy multiple system atrophy (MSA).

Methods

¹⁸ F-DA-derived radioactivity in the heart, li

SUBMITTER: Lamotte G 

PROVIDER: S-EPMC7732242 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature