Corpus callosum integrity loss predicts cognitive impairment in Leukoaraiosis.

ABSTRACT:

Objective

To investigate regional white matter fibers loss in Leukoaraiosis (LA) and its relationship with cognitive impairments.

Methods

Fifty-six participants with LA and 38 healthy controls underwent clinical evaluations and MR scans. Participants with LA were classified as cognitively normal (LA-NC, n = 18), vascular cognitive impairment of none dementia (LA-VCIND, n = 24), and vascular dementia (LA-VaD, n = 14) by Mini-Mental State Examination and Clinical Dementia Rating. Cognitive domains including visual-spatial, naming, attention, language, abstraction, memory, and orientation were assessed. With the use of Tract-based spatial statistics, mean fractional anisotropy (FA) of major white matter fiber tracts were compared between LA and controls and among LA groups with

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7732249 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature