Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets.

ABSTRACT:

Background

As the important components in polycomb repressive complexes 1 (PRC1) and heterochromatin protein 1 (HP1), Chromobox (CBX) family members are involved in epigenetic regulatory function, transcriptional repression, and other cellular metabolisms. Increasing studies have indicated significant associations between CBX and tumorigenesis, which is a progression in different types of cancers. However, the information about the roles of each CBX in gastric cancer is extremely limited.

Methods

We explored CBX mRNA expression, corrections with clinicopathological parameters, protein expression, prognostic values, enrichment analysis with several databases including Oncomine, Human Protein Atlas, UALCAN, Kaplan-Meier plotter, cBioPortal, GeneMANIA, and Enrichr.

Results</

SUBMITTER: Chen ZY 

PROVIDER: S-EPMC7732380 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature