Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection.

ABSTRACT:

Background

Considering the complexity of the factors involved in the immunopathology of Chagas disease, which influence the Chagas' disease pathogenesis, anti-T. cruzi immune response, and chemotherapy outcome, further studies are needed to improve our understanding about these relationships. On this way, in this article we analyzed the host genetic influence on hematological, histopathological and immunological aspects after T. cruzi infection.

Methods

BALB/c and A mice were intragastrically infected with T. cruzi SC2005 strain, isolated from a patient of an outbreak of Chagas disease. Parameters such as parasite load, survival rates, cytokines production, macrophages, T and B cell frequencies, and histopathology analysis were carried out.

Results

SUBMITTER: Domingues CS 

PROVIDER: S-EPMC7732431 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature