Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life.

ABSTRACT: Neonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform. We found increasing acute phase proteins and a reduction of respective inhibitors on DOL1. Focusing on the complement system, we found increased plasma concentrations of all major co

SUBMITTER: Bennike TB 

PROVIDER: S-EPMC7732455 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature