Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model.

ABSTRACT: Tumor cells without mitochondrial (mt) DNA (ρ⁰ cells) are auxotrophic for uridine, and their growth is supported by pyruvate. While ATP synthesis in ρ⁰ cells relies on glycolysis, they fail to form tumors unless they acquire mitochondria from stromal cells. Mitochondrial acquisition restores respiration that is essential for de novo pyrimidine biosynthesis and for mitochondrial ATP production. The physiological processes that underpin intercellular mitochondrial transfer to tumor cells lacking mtDNA and the metabolic remodeling and restored tumorigenic properties of cells that acquire mitochondria are not well understood. Here, we investigated the changes in mitochondrial and nuclear gene expression that accompany mtDNA deletion and acquisition in metastatic mu

SUBMITTER: Grasso C 

PROVIDER: S-EPMC7732479 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature