HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice.

ABSTRACT: Adult neurogenesis, a striking form of neural plasticity, is involved in the modulation of social stimuli driving reproduction. Previous studies on adult neurogenesis have shown that this process is significantly modulated around puberty in female mice. Puberty is a critical developmental period triggered by increased secretion of the gonadotropin releasing hormone (GnRH), which controls the activity of the hypothalamic-pituitary-gonadal axis (HPG). Secretion of HPG-axis factors at puberty participates to the refinement of neural circuits that govern reproduction. Here, by exploiting a transgenic GnRH deficient mouse model, that progressively loses GnRH expression during postnatal development (GnRH::Cre;Dicer ^loxP/loxP mice), we found that a postnatal

SUBMITTER: Trova S 

PROVIDER: S-EPMC7732626 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature