Extreme Antagonism Arising from Gene-Environment Interactions.

ABSTRACT: Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or function. Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterious perturbation compensates for the function lost because of a prior perturbation. Here, we report on gene-environment interactions involving genetic mutations that are deleterious in a permissive environment but beneficial in a specific environment that restricts growth. These extreme antagonistic interactions constitute gene-environment analogs of synthetic rescues previously observed for gene-gene interactions. Our approach uses two independent adaptive evolution steps to

SUBMITTER: Wytock TP 

PROVIDER: S-EPMC7732749 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature