Constitutive Model of Erythrocyte Membranes with Distributions of Spectrin Orientations and Lengths.

ABSTRACT: We present an analytical hyperelastic constitutive model of the red blood cell (erythrocyte) membrane based on recently improved characterizations of density and microscopic structure of its spectrin network from proteomics and cryo-electron tomography. The model includes distributions of both orientations and natural lengths of spectrin and updated copy numbers of proteins. By applying finite deformation to the spectrin network, we obtain the total free energy and stresses in terms of invariants of shear and area deformation. We generalize an expression of the initial shear modulus, which is independent of the number of molecular orientations within the network and also derive a simplified version of the model. We apply the model and its simplified version to analyze micropipette aspirati

SUBMITTER: Feng Z 

PROVIDER: S-EPMC7732770 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature