Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices.

ABSTRACT: CD8⁺ cytotoxic T lymphocytes (CTL) and natural killer cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (also known as target cells). To find their targets, they have to navigate and migrate through complex biological microenvironments, a key component of which is the extracellular matrix (ECM). The mechanisms underlying killer cell's navigation are not well understood. To mimic an ECM, we use a matrix formed by different collagen concentrations and analyze migration trajectories of primary human CTLs. Different migration patterns are observed and can be grouped into three motility types: slow, fast, and mixed. The dynamics are well described by a two-state persistent random walk model, which allows cells to switch be

SUBMITTER: Sadjadi Z 

PROVIDER: S-EPMC7732778 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature