NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis.

ABSTRACT: Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT) cells can be activated to rapidly secrete cytokines and chemokines associated with both type 1 and type 2 inflammatory responses. As these proteins have been reported to accumulate in different types of sterile liver inflammation, we hypothesized that these cells may play a role in this pathological process. We have found that a transgenic NKT (tgNKT) cell population produced in the immunodeficient 2,4αβNOD.Rag2^-/- mice, but not in 2,4αβNOD.Rag2^+/- cont

SUBMITTER: Nilsson J 

PROVIDER: S-EPMC7732838 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature