Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.

ABSTRACT: The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson's disease and related disorders. However, the mechanisms by which α-synuclein influences disease onset and progression are incompletely understood. To identify pathogenic pathways and therapeutic targets we performed proteomic analysis in a highly penetrant new Drosophila model of α-synucleinopathy. We identified 476 significantly upregulated and 563 significantly downregulated proteins in heads from α-synucleinopathy model flies compared to controls. We then used multiple complementary analyses to identify and prioritize genes and pathways within the large set of differentially expressed proteins for functional studies. We performed Gene Ontology enrichment analysis, integrated

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC7732845 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature