Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants.

ABSTRACT: Burn wounds are highly susceptible sites for colonization and infection by bacteria and fungi. Large wound surface, impaired local immunity, and broad-spectrum antibiotic therapy support growth of opportunistic fungi such as Candida albicans, which may lead to invasive candidiasis. Currently, it remains unknown whether depressed host defenses or fungal virulence drive the progression of burn wound candidiasis. Here we established an ex vivo burn wound model, where wounds were inflicted by applying preheated soldering iron to human skin explants, resulting in highly reproducible deep second-degree burn wounds. Eschar removal by debridement allowed for deeper C. albicans penetration into the burned tissue associated with prominent filamentation. Active migration of resident tissue neutrophil

SUBMITTER: von Muller C 

PROVIDER: S-EPMC7732850 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature