A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle.

ABSTRACT: Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles. However, ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc. As these incidents could easily introduce new microbial pathogens in/onto the implants. Herein, we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning, could effectively eradicate bacterial infection at various stages of implantation. Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating. Antibacterial effect at intermediate stage was mediated by s

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7732879 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature