Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress.

ABSTRACT: Endothelial function declines progressively across stages of the menopause transition; however, the mechanisms contributing to this decline are unknown. We hypothesized that differences in endothelial function among pre-, peri, and postmenopausal women are related to differences in estradiol and oxidative stress. Brachial artery flow-mediated dilation (FMD) was measured in 87 healthy women categorized by menopause stage (24 premenopausal, 17 early and 21 late perimenopausal, and 25 postmenopausal) before and after 3 days of ovarian hormone suppression (gonadotropin releasing hormone antagonist [GnRH_ant]) alone, and an additional 3 days of GnRH_ant with concurrent transdermal estradiol or placebo add-back treatment. In 82 women, FMD during acute vitamin C (antioxidant)

SUBMITTER: Moreau KL 

PROVIDER: S-EPMC7732894 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature