Goal-directed perfusion to reduce acute kidney injury after paediatric cardiac surgery (GDP-AKIp): study protocol for a prospective randomised controlled trial.

ABSTRACT:

Introduction

Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in up to 40%~60% of paediatric patients and increases postoperative morbidity and mortality. A goal-directed perfusion (GDP) strategy aimed at maintaining indexed oxygen delivery (DO₂i) above the critical threshold (reported to be 260~300 mL/min/m² in adults) during cardiopulmonary bypass (CPB), is effective in reducing the incidence of CS-AKI. However, no clear standards of paediatric critical DO₂i exist. Our prior prospective cohort study exploring the critical DO₂i threshold during paediatric CPB has found the nadir DO₂i <353 mL/min/m² was an independent risk predictor of CS-AKI. Based on this background, this trial is designed to further

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7733190 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature