Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment.

ABSTRACT:

Background

Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date, the roles and mechanisms of IL-33 in tumours remain controversial. Here, we examined the effect of exogenous IL-33 on the biological characteristics of hepatocellular carcinoma (HCC) and the possible mechanism of action.

Methods

In this study, IL-33 expression in the tissues of 69 HCC patients was detected and its relationship with prognosis was evaluated. After establishing a mouse HCC model and IL-33 treatment operation, the infiltration of splenic myeloid-derived suppressor (MDSCs), dendritic (DCs), regulatory T, and natural killer (NK) cells was detected

SUBMITTER: Wang W 

PROVIDER: S-EPMC7733302 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature