Evidence of relative iron deficiency in platelet- and plasma-pheresis donors correlates with donation frequency.

ABSTRACT:

Background

The loss of iron stores and resulting iron deficiency is well documented in whole blood or red blood cell donors. We hypothesized that relative iron deficiency also occurs as a result of more frequent platelet- and plasma-pheresis (apheresis) donation.

Materials and methods

To test this hypothesis, we proposed a pilot cross-sectional study to analyze erythropoiesis- and iron-related parameters in white male apheresis donors: (1) relative to controls, (2) in correlation with apheresis donation frequency, and (3) in correlation with pre-donation platelet count.

Results

Fifty eligible apheresis donors and eight controls were enrolled in the study. Apheresis donors were found to have a lower serum ferritin and serum hepcidin and exhibited evidence of iron restr

SUBMITTER: Li H 

PROVIDER: S-EPMC7733305 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature