Understanding the asthmatic response to an experimental rhinovirus infection: Exploring the effects of blocking IgE.

ABSTRACT:

Background

Rhinovirus frequently causes asthma exacerbations among children and young adults who are allergic. The interaction between allergen and rhinovirus-induced symptoms and inflammation over time is unclear.

Objective

Our aim was to compare the response to an experimental inoculation with rhinovirus-16 in allergic asthmatics with the response in healthy controls and to evaluate the effects of administrating omalizumab before and during the infection.

Methods

Two clinical trials were run in parallel. In one of these trials, the response to an experimental inoculation with rhinovirus-16 among asthmatics with high levels of total IgE was compared to the response in healthy controls. The other trial compared the effects of administering omalizumab versus placebo to

SUBMITTER: Heymann PW 

PROVIDER: S-EPMC7733370 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature