Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy.

ABSTRACT: [¹⁸F]fluorodeoxyglucose (FDG) PET and [¹²³I]metaiodobenzylguanidine (MIBG) scintigraphy may contribute to the differential diagnosis of neurodegenerative parkinsonism. To identify the superior method, we retrospectively evaluated 54 patients with suspected neurodegenerative parkinsonism, who were referred for FDG PET and MIBG scintigraphy. Two investigators visually assessed FDG PET scans using an ordinal 6-step score for disease-specific patterns of Lewy body diseases (LBD) or atypical parkinsonism (APS) and assigned the latter to the subgroups multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal syndrome. Regions-of-interest analysis on anterior planar MIBG images served to calculate the heart-to-mediastinum ratio. Movement disorder s

SUBMITTER: Brumberg J 

PROVIDER: S-EPMC7733458 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature