The plasminogen receptor, Plg-R_KT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice.

ABSTRACT: Wound healing is a complex physiologic process that proceeds in overlapping, sequential steps. Plasminogen promotes fibrinolysis and potentiates the inflammatory response during wound healing. We have tested the hypothesis that the novel plasminogen receptor, Plg-R_KT, regulates key steps in wound healing. Standardized burn wounds were induced in mice and time dependence of wound closure was quantified. Healing in Plg-R_KT^-/- mice was significantly delayed during the proliferation phase. Expression of inflammatory cytokines was dysregulated in Plg-R_KT^-/- wound tissue. Consistent with dysregulated cytokine expression, a significant delay in wound healing during the proliferation phase was observed in mice in which Plg-R_KT was s

SUBMITTER: Ny L 

PROVIDER: S-EPMC7733490 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature