Differential longitudinal establishment of human fecal bacterial communities in germ-free porcine and murine models.

ABSTRACT: The majority of microbiome studies focused on understanding mechanistic relationships between the host and the microbiota have used mice and other rodents as the model of choice. However, the domestic pig is a relevant model that is currently underutilized for human microbiome investigations. In this study, we performed a direct comparison of the engraftment of fecal bacterial communities from human donors between human microbiota-associated (HMA) piglet and mouse models under identical dietary conditions. Analysis of 16S rRNA genes using amplicon sequence variants (ASVs) revealed that with the exception of early microbiota from infants, the more mature microbiotas tested established better in the HMA piglets compared to HMA mice. Of interest was the greater transplantation success of memb

SUBMITTER: Aluthge ND 

PROVIDER: S-EPMC7733510 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature