SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8⁺ T cells.

ABSTRACT: The prevailing 'division of labor' concept in cellular immunity is that CD8⁺ T cells primarily utilize cytotoxic functions to kill target cells, while CD4⁺ T cells exert helper/inducer functions. Multiple subsets of CD4⁺ memory T cells have been characterized by distinct chemokine receptor expression. Here, we demonstrate that analogous CD8⁺ memory T-cell subsets exist, characterized by identical chemokine receptor expression signatures and controlled by similar generic programs. Among them, Tc2, Tc17 and Tc22 cells, in contrast to Tc1 and Tc17 + 1 cells, express IL-6R but not SLAMF7, completely lack cytotoxicity and instead display helper functions including CD40L expression. CD8⁺ helper T cells exhibit a unique TCR repertoire, expres

SUBMITTER: Loyal L 

PROVIDER: S-EPMC7733515 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature