Longitudinal sampling is required to maximize detection of intrahost A/H3N2 virus variants.

ABSTRACT: Seasonal human influenza viruses continually change antigenically to escape from neutralizing antibodies. It remains unclear how genetic variation in the intrahost virus population and selection at the level of individual hosts translates to the fast-paced evolution observed at the global level because emerging intrahost antigenic variants are rarely detected. We tracked intrahost variants in the hemagglutinin and neuraminidase surface proteins using longitudinally collected samples from 52 patients infected by A/H3N2 influenza virus, mostly young children, who received oseltamivir treatment. We identified emerging putative antigenic variants and oseltamivir-resistant variants, most of which remained detectable in samples collected at subsequent days, and identified variants that emerged i

SUBMITTER: Koel BF 

PROVIDER: S-EPMC7733607 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature