Pre-operative withholding of infliximab and the risk of infections after major surgery in patients with rheumatoid arthritis.

ABSTRACT:

Objectives

Withholding TNF inhibitors (TNFI) before surgery has been recommended due to concern for post-operative infection. We examined the risks of post-operative infections and mortality in patients with RA in relation to the pre-operative timing of infliximab infusion.

Methods

In this population-based retrospective cohort study, we used US Medicare claims data from 2007 to 2015 to identify patients with RA who underwent coronary artery bypass grafting (CABG), aortic or vascular surgery, or bowel resection, and who were treated with infliximab in the 90 days prior to surgery. We examined associations between the timing of infusion and infections and mortality in the 30 days after surgery. We adjusted for the predicted probability of post-operative infection or death, dem

SUBMITTER: Ward MM 

PROVIDER: S-EPMC7733718 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature