Renal deposits of complement factors as predictors of end-stage renal disease and death in patients with lupus nephritis.

ABSTRACT:

Objective

Lupus nephritis (LN) increases the risks of end-stage renal disease (ESRD) and death, but these risks are difficult to estimate. Since complement factors play an essential role in the pathogenesis and are deposited in the kidneys as C1q and C3, we studied whether these deposits predict ESRD and death in patients with LN.

Methods

We collected demographic, clinical and pathological data from 183 adult patients with LN classes II-V diagnosed with a first native kidney biopsy. Pathological data included the localization and intensity of immunofluorescence staining of C1q and C3. We obtained dates of incident ESRD and death from the United States Renal Data System and National Death Index, respectively, and evaluated survival curves and hazard ratios for ESRD and death

SUBMITTER: Koopman JJE 

PROVIDER: S-EPMC7733722 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature