Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy.

ABSTRACT: The function of the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex. The LINC complex spans the nuclear envelope and mediates nuclear mechanotransduction, the process by which mechanical signals and forces are transmitted across the nuclear envelope. In turn, the AAA+ ATPase torsinA is thought to regulate force transmission from the cytoskeleton to the nucleus. In humans, mutations affecting nuclear envelope-associated proteins cause laminopathies, including progeria, myopathy, and dystonia, though the extent to which endogenous mechanical stresses contribute to these pathologies is unclear. Here, we use the Caenorhabditis elegans germline as a model to investigate m

SUBMITTER: Huelgas-Morales G 

PROVIDER: S-EPMC7733798 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature