Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6.

ABSTRACT: Next-generation sequencing technologies allowed sequencing of thousands of genomes. However, there are genomic regions that remain difficult to characterize, including telomeres, centromeres, and other low-complexity regions, as well as transposable elements and endogenous viruses. Human herpesvirus 6A and 6B (HHV-6A and HHV-6B) are closely related viruses that infect most humans and can integrate their genomes into the telomeres of infected cells. Integration also occurs in germ cells, meaning that the virus can be inherited and result in individuals harboring the virus in every cell of their body. The integrated virus can reactivate and cause disease in humans. While it is well established that the virus resides in the telomere region, the integration locus is poorly defined due to the l

SUBMITTER: Wight DJ 

PROVIDER: S-EPMC7733811 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature