Rubella seroprevalence using residual samples from the South African measles surveillance program: a cross-sectional analytic study.

ABSTRACT: Introduction: South Africa is yet to introduce rubella-containing vaccines (RCV) into its routine immunization schedule. Selecting the target population when introducing RCV should take into account the ages of susceptible individuals in the population. We aimed to determine the seroprevalence of antibodies to rubella and characterize immunity gaps among individuals of all ages in South Africa. Methods: We tested for rubella immunoglobulin G (IgG) antibodies with a commercial enzyme-linked immunosorbent assay. We used residual samples collected from 2016 through 2018 as part of the national measles surveillance program. We only tested samples that were negative for measles and rubella immunoglobulin M (IgM) and explored the association between rubella susceptibility (IgG nega

SUBMITTER: Motaze NV 

PROVIDER: S-EPMC7733892 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature