Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium Akkermansia muciniphila.

ABSTRACT: The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain Muc^T is known to use cobamides, the vitamin B₁₂ family of cofactors with structural diversity in the lower ligand. However, A. muciniphila Muc^T is unable to synthesize cobamides de novo, and the specific forms that can be used by A. muciniphila have not been examined. We found that the levels of growth of A. muciniphila Muc^T were nearly identical with each of seven cobamides tested, in contrast to nearly all bacteria that had been studied previously. Unexpectedly, this

SUBMITTER: Mok KC 

PROVIDER: S-EPMC7733943 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature