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Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study.

ABSTRACT: Using normalization of CD4 counts as the main evaluation parameter of complete immune restoration for HIV-1 patients under antiretroviral therapy (ART) might be not enough. A comprehensive evaluation system more accurately reflecting immune restoration are urgently needed. Totally, 91,805 HIV-1 patients from 17 tertiary hospitals in China during 2005-2018 were included in this study. Immune restoration and mortality were assessed. Patients initiated ART with baseline CD4 counts <50, 50-199, 200-349, 350-499, and ≥500 cells/μL, and results showed an increase in the median CD4 counts to 445 (12-year), 467 (12-year), 581 (11-year), 644 (7-year), and 768 cells/µL (5-year), as well as the CD4/CD8 ratio to 0.59 (12-year), 0.65 (12-year), 0.79 (11-year), 0.82 (7-year), 0.9 (5-year), respectively. The median CD8 count was relatively high (median range 732-845 cells/μL), regardless of the baseline CD4 counts. Furthermore, the probabilities of death in patients achieving CD4 counts ≥500 cells/μL and CD4/CD8 ratio ≥0.8 simultaneously were significantly lower than those in patients achieving either CD4 counts ≥500 cells/μL (2.77% vs 3.50%, p=0.02) or CD4/CD8 ≥ 0.8 (2.77% vs 4.28%, p<0.001) after 12-year of ART. In this study, a new binary-indicator would accurately assess immune restoration in the era of "treat all."

SUBMITTER: Liu J

PROVIDER: S-EPMC7733958 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study.

Liu Jiaye J Wang Lifeng L Hou Yuying Y Zhao Yan Y Dou Zhihui Z Ma Ye Y Zhang Dawei D Wu Yasong Y Zhao Decai D Liu Zhongfu Z Zhang Fujie F Jin Lei L Zhang Ji-Yuan JY Xu Ruonan R Shi Ming M Huang Lei L Wu Zunyou Z Han Mengjie M Gao George F GF Wang Fu-Sheng FS

Emerging microbes & infections 20201201 1

Using normalization of CD4 counts as the main evaluation parameter of complete immune restoration for HIV-1 patients under antiretroviral therapy (ART) might be not enough. A comprehensive evaluation system more accurately reflecting immune restoration are urgently needed. Totally, 91,805 HIV-1 patients from 17 tertiary hospitals in China during 2005-2018 were included in this study. Immune restoration and mortality were assessed. Patients initiated ART with baseline CD4 counts <50, 50-199, 200- ...[more]

PMID: 33131455

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Dataset Information

Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study.

Publications

Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study.

Similar Datasets

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