CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling.

ABSTRACT: Stromal invasion is considered an important prognostic factor in patients with lung adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal invasion have been studied in the lung; however, they are still unclear. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein highly expressed in several types of human malignant tumors including lung cancers. In this study, we investigated the in vivo functions of CD109 protein in malignant lung tumors. Initially, we identified an association between higher expression of CD109 protein in human lung adenocarcinoma and a significantly worse prognosis, according to immunohistochemical analysis. We also showed that CD109 deficiency significantly reduced the area of stromal invasive lesions in a genetically engineered C

SUBMITTER: Taki T 

PROVIDER: S-EPMC7734007 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature