Long Non-coding RNAs in Cancer: Implications for Diagnosis, Prognosis, and Therapy.

ABSTRACT: Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are arising as important players in various biological pathways. They have received extensive attention in recent years, regarded to be involved in both developmental processes and various diseases. Due to their specific expression and functional diversity in a variety of cancers, lncRNAs have promising applications in cancer diagnosis, prognosis and therapy. Studies have shown that lncRNAs with high specificity and accuracy have the potential to become biomarkers in cancers. LncRNAs can be noninvasively extracted from body fluids, tissues and cells, and can be used as independent or auxiliary biomarkers to improve the accuracy of diagnosis or prognosis. Currently, the most well-recognized lncRNA is PCA3, whic

SUBMITTER: Qian Y 

PROVIDER: S-EPMC7734181 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature