Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells.

ABSTRACT: Recent reports have shown the importance of IFN-γ and T-bet⁺ B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet⁺ CD4⁺ cells, i.e., Th1 cells. This study determined the changes in Th1 subsets with metabolic shift and their potential as therapeutic targets in SLE. Compared with healthy donors, patients with SLE had higher numbers of T-bet^hiCXCR3^lo effector cells and T-bet⁺Foxp3^lo non-suppressive cells, which excessively produce IFN-γ, and lower number of non-IFN-γ-producing T-bet⁺Foxp3^hi activated-T_reg cells. These changes were considered to be involved in treatment resistance. The differentiation mechanism of Th1 subsets was investigated in vitro

SUBMITTER: Iwata S 

PROVIDER: S-EPMC7734283 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature