Pre-concentration by liquid intake by paper (P-CLIP): a new technique for large volumes and digital microfluidics.

ABSTRACT: Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-to-chip" interface - it is challenging to detect analytes present at low concentrations in systems that can only handle small volumes of sample. Here we describe a new technique termed pre-concentration by liquid intake by paper (P-CLIP) that addresses this mismatch, allowing digital microfluidics to interface with volumes on the order of hundreds of microliters. In P-CLIP, a virtual microchannel is generated to pass a large volume through the device; analytes captured on magnetic particles can be isolated and then resuspended into smaller volumes for further processing and analysi

SUBMITTER: Rackus DG 

PROVIDER: S-EPMC7734381 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature