Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections.

ABSTRACT: Zoonotic spillover, i.e. pathogen transmission from animal to human, has repeatedly introduced RNA viruses into the human population. In some cases, where these viruses were then efficiently transmitted between humans, they caused large disease outbreaks such as the 1918 flu pandemic or, more recently, outbreaks of Ebola and Coronavirus disease. These examples demonstrate that RNA viruses pose an immense burden on individual and public health with outbreaks threatening the economy and social cohesion within and across borders. And while emerging RNA viruses are introduced more frequently as human activities increasingly disrupt wild-life eco-systems, therapeutic or preventative medicines satisfying the "one drug-multiple bugs"-aim are unavailable. As one central aspect of preparedness effo

SUBMITTER: Huchting J 

PROVIDER: S-EPMC7734526 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature