Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment.

ABSTRACT: The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. Here, we report functional restoration and morphological reorganization after spinal contusion in pigs, following a combined treatment of locomotor training facilitated with epidural electrical stimulation (EES) and cell-mediated triple gene therapy with umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial-derived neurotrophic factor, and neural cell adhesion molecule. Preliminary results obtained on a small sample of pigs 2 months after spinal contusion revealed the difference in post-traumatic spinal cord outcomes in control and treated animals. In treated pigs, motor pe

SUBMITTER: Islamov R 

PROVIDER: S-EPMC7734573 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature