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Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.


ABSTRACT: There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.

SUBMITTER: Diorio C 

PROVIDER: S-EPMC7734626 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.

Diorio Caroline C   Anderson Elizabeth M EM   McNerney Kevin O KO   Goodwin Eileen C EC   Chase Julie C JC   Bolton Marcus J MJ   Arevalo Claudia P CP   Weirick Madison E ME   Gouma Sigrid S   Vella Laura A LA   Henrickson Sarah E SE   Chiotos Kathleen K   Fitzgerald Julie C JC   Kilbaugh Todd J TJ   John Audrey R Odom ARO   Blatz Allison M AM   Lambert Michele P MP   Sullivan Kathleen E KE   Tartaglione Margaret R MR   Zambrano Danielle D   Martin Meghan M   Lee Jessica H JH   Young Pampee P   Friedman David D   Sesok-Pizzini Deborah A DA   Hensley Scott E SE   Behrens Edward M EM   Bassiri Hamid H   Teachey David T DT  

Pediatric blood & cancer 20200904 11


There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody l  ...[more]

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2022-04-12 | GSE182183 | GEO