Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.

ABSTRACT:

Background

Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time lead to chronic inflammation and COPD. We hypothesized that-among COPD patients-the same mechanism would affect rate of decline in lung function; specifically, that a decreased expression of Tregs would be associated with a more rapid decline in FEV₁.

Methods

Bronchoscopy with BAL was performed in 52 subjects recruited from the longitudinal OLIN COPD study; 12 with COPD and a rapid decline in lung function (loss of FEV₁ ≥ 60 ml/year), 10 wit

SUBMITTER: Eriksson Strom J 

PROVIDER: S-EPMC7734742 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature