Staurosporine Analogs Via C-H Borylation.

ABSTRACT: Staurosporine is among the most potent naturally occurring kinase inhibitors isolated to date and has served as a lead compound for numerous drug development efforts in several therapeutic areas. Herein we report that C-H borylation chemistry provides access to analogs of staurosporine that were previously inaccessible to medicinal chemists who, in the past four decades, have prepared over 1000 semisynthetic staurosporine analogs.

SUBMITTER: Gayler KM 

PROVIDER: S-EPMC7734790 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature