Altered metabolism of mothers of young children with Autism Spectrum Disorder: a case control study.

ABSTRACT:

Background

Previous research studies have demonstrated abnormalities in the metabolism of mothers of young children with autism.

Methods

Metabolic analysis was performed on blood samples from 30 mothers of young children with Autism Spectrum Disorder (ASD-M) and from 29 mothers of young typically-developing children (TD-M). Targeted metabolic analysis focusing on the folate one-carbon metabolism (FOCM) and the transsulfuration pathway (TS) as well as broad metabolic analysis were performed. Statistical analysis of the data involved both univariate and multivariate statistical methods.

Results

Univariate analysis revealed significant differences in 5 metabolites from the folate one-carbon metabolism and the transsulfuration pathway and differences in an additional 48 m

SUBMITTER: Hollowood-Jones K 

PROVIDER: S-EPMC7734806 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature