Transcriptome analysis reveals modulation of the STAT family in PEDV-infected IPEC-J2 cells.

ABSTRACT:

Background

Porcine epidemic diarrhea virus (PEDV) is a causative agent of serious viral enteric disease in suckling pigs. Such diseases cause considerable economic losses in the global swine industry. Enhancing our knowledge of PEDV-induced transcriptomic responses in host cells is imperative to understanding the molecular mechanisms involved in the immune response. Here, we analyzed the transcriptomic profile of intestinal porcine epithelial cell line J2 (IPEC-J2) after infection with a classical strain of PEDV to explore the host response.

Results

In total, 854 genes were significantly differentially expressed after PEDV infection, including 716 upregulated and 138 downregulated genes. Functional annotation analysis revealed that the differentially expressed genes were mai

SUBMITTER: Hu Z 

PROVIDER: S-EPMC7734901 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature